U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRX20094123: GSM7225502: Pristina leidyi, whole-body, scRNA-seq, batch 3, library 30; Pristina leidyi; RNA-Seq
8 ILLUMINA (Illumina NovaSeq 6000) runs: 1.4G spots, 434.5G bases, 140.5Gb downloads

External Id: GSM7225502_r1
Submitted by: Department of Biological and Medical Sciences, Oxford Brookes University
Study: Annelid adult cell type diversity and their pluripotent cellular origins
show Abstracthide Abstract
We used scRNA-seq to profile 75,218 single cell transcriptomes of Pristina leidyi, a highly regenerative and asexually-reproducing freshwater annelid. We characterized all major adult cell types, their transcription factors and gene networks, and uncovered an abundant population of putative stem cells with a pluripotent signature. Overall design: We obtained cell dissociations from adult populations of Pristina leidyi containing intact organisms at mixed stages, including fission stages. PacBio Iso-Seq sequencing was done on a single mixed sample, and no quantitative analysis is intended from the sample.
Sample: Pristina leidyi, whole-body, scRNA-seq, batch 3, library 30
SAMN34360746 • SRS17425636 • All experiments • All runs
Organism: Pristina leidyi
Library:
Name: GSM7225502
Instrument: Illumina NovaSeq 6000
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC SINGLE CELL
Selection: cDNA
Layout: PAIRED
Construction protocol: We used ACME dissociation to dissociate whole animals into fixed and permeable cell suspensions. Dissociated cells were proccessed using a SPLiT-seq protocol (we sorted singlets by FACS during SPLiT-seq, right before the cell lysis step). We followed the SPLiT-seq library construction pipeline (Dynabeads cDNA purification, template switching, PCR amplification, size selection, tagmentation, indexed-PCR amplification and second size selection). Size selection was performed using Roche KAPA Pure Beads at 0.6X-0.8X ratios. Tagmentation was performed using the Nextera XT DNA Library Preparation Kit (Illumina) according to the manufacturer´s instructions.
Runs: 8 runs, 1.4G spots, 434.5G bases, 140.5Gb
Run# of Spots# of BasesSizePublished
SRR2429874321,787,3456.5G2.3Gb2023-04-28
SRR2429874421,706,9326.5G2.3Gb2023-04-28
SRR2429874524,812,0537.4G2.7Gb2023-04-28
SRR2429874626,109,6397.8G2.8Gb2023-04-28
SRR24298747321,642,83496.5G31.2Gb2023-04-28
SRR24298748313,820,41294.1G30.5Gb2023-04-28
SRR24298749355,784,537106.7G34.3Gb2023-04-28
SRR24298750362,519,127108.8G34.5Gb2023-04-28

ID:
27497541

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...